Come on Sarah

[Van wink 2,994]

20 minutes ago, Well b back said:

Our friend Sarah must be very stressed this morning.

Don’t know much about vaccine trials Wbb but my suspicion is that this event is something not unexpected and hopefully she will be taking it in her stride😀

[Tetteys Jig 830]

5 hours ago, Tetteys Jig said:

Being reported it is Transverse Myelitis. Got to confess I'd never heard of it before today. Hopefully not vaccine related

apparently it is the same reason it was paused in July/August, someone getting the same thing. Seems it wasn't to do with the vaccine. Not now sure what the reason is for this pause

Edited September 9, 2020 by Tetteys Jig

[Yellow Fever 3,749]

53 minutes ago, Tetteys Jig said:

apparently it is the same reason it was paused in July/August, someone getting the same thing. Seems it wasn't to do with the vaccine. Not now sure what the reason is for this pause

If true - 2 'rare' but identical (or related) diseases will give rather more than a simple pause for thought. Lightning strike twice is unlikely to be random chance. Any let's hope not.

 

[Creative Midfielder 1,985]

52 minutes ago, Tetteys Jig said:

Being reported it is Transverse Myelitis. Got to confess I'd never heard of it before today. Hopefully not vaccine related

apparently it is the same reason it was paused in July/August, someone getting the same thing. Seems it wasn't to do with the vaccine. Not now sure what the reason is for this pause

If this is a very rare condition, which I believe it is, wouldn't even two instances of it in the trial be a cause for concern or is it just a case of sheer bad luck?

Must admit I've never really understood how statisticians reach their conclusions about what is (and isn't) statistically significant.

[Yellow Fever 3,749]

10 minutes ago, Creative Midfielder said:

If this is a very rare condition, which I believe it is, wouldn't even two instances of it in the trial be a cause for concern or is it just a case of sheer bad luck?

Must admit I've never really understood how statisticians reach their conclusions about what is (and isn't) statistically significant.

If it's 1 in a million (twice) or even 1 in 10,000 (twice)  I would be VERY concerned!

[Tetteys Jig 830]

Since the placebo is a meningitis jab that has it as a rare side effect already, perhaps its as a result of getting that jab? Sounds like its not the reason for this pause anyway, so its only 1 confirmed instance of it now.

[It's Character Forming 1,160]

People might want to take a look at the side-effects listed for everyday medicines like paracetamol.  All medicine has side-effects in some cases, it's about how many and how serious.

 

It's definitely a blow that this has happened, but with luck it won't be a problem, it's got to be checked properly and hopefully it's alright.

This is why Whitty has been hedged in his statements about the chances of having a vaccine available this year - he knows it's entirely possible the Oxford vaccine will be tripped up by something like this.

 

Also this shows how absolutely crazy it has been for Russia (79 people tested !) and China to start implementing their vaccines without completed Phase III testing.  Both of them are gambling with the health of people taking the vaccines by not testing them properly.  If either of them go wrong, we'll all suffer because it will just give the bonkers anti-vaxxers ammunition for their arguments.

[Well b back 3,190]

Just heard them in the conference about this and they didn’t sound to concerned. I can see no mention the other one had this same problem anywhere, however I can see the delay was only a couple of days suggesting it was someone that did not have the vaccine but the placebo.

[Well b back 3,190]

I never wanted this to get political but just listening to him he has lost the plot. I am a diabetic, our son starts college tomorrow, and I will stand to be corrected but he just said I have to shield from him ?.

We all know on this thread Oxford advised that by changing the message to stay aware and not bringing younger people back into line where we are now, was exactly where Oxford told us we would be. Do Oxford know more than the scientists ? Or is he just ignoring the scientific advise ? Which vaccine related will anyone trust him when he says the vaccine is ready or even says although other Countries are vaccinating we are not as we don’t think it’s safe ?

[Tetteys Jig 830]

https://mobile.twitter.com/statnews/status/1303722580642328579 patient spoil sport perhaps ready to be released today, hopefully the trial can continue soon!

[It's Character Forming 1,160]

Worth bookmarking this statnews website which is a specialist medical website and is the one which broke the story originally;

https://www.statnews.com/2020/09/08/astrazeneca-covid-19-vaccine-study-put-on-hold-due-to-suspected-adverse-reaction-in-participant-in-the-u-k/

makes a lot more sense than what I see in the mainstream media

[Well b back 3,190]

I need to read it’s character forming link but in the meantime I like these words

The pause will delay the progress of the vaccine making the possibility of it being ready this year much less likely. But experts expect the trials, which are being run in the UK, Brazil and the US, will almost certainly be allowed to continue.

 

[Well b back 3,190]

There you go it’s character Forming I have made it to a link lol. I notice in that article again there is no mention of this being the same as the first one, in fact the opposite as it says they are trawling data for ALL vaccines to see if this has happened before. It also seems to confirm Trumps story that they were ready for US emergency use at the end of October. Have Oxford just accidentally put Biden in the Whitehouse lol

https://www.statnews.com/2020/09/08/astrazeneca-covid-19-vaccine-study-put-on-hold-due-to-suspected-adverse-reaction-in-participant-in-the-u-k/

 

 

 

 

[Well b back 3,190]

Here’s more and interestingly reports that the first guy had the thing we have been talking about and was nothing to do with the vaccine. It has not been disclosed what is wrong with second person. Sounds like whatever it is though a full recovery is expected.

https://www.nature.com/articles/d41586-020-02594-w

 

[It's Character Forming 1,160]

Thanks WBB

 

https://www.statnews.com/2020/09/09/astrazeneca-covid19-vaccine-trial-hold-patient-report/

 

this gives an update with the specific details (not that I’m really any the wiser about the condition).

 

this says it is different from the previous case which was unconnected to the vaccine. It’s not clear yet whether this case is linked to the vaccine.

 

the Economist has made the point with some medicines /vaccines, people with some conditions are ruled out from taking them.

 

As you say, this could and probably will make the “best case” timescale slip and that’s got to be a problem for Trump, silver linings etc 😉

[Well b back 3,190]

This is worrying regards the spread. Hopefully our kids are more sensible

U.S. colleges that have reopened for in-person instruction are struggling to contain the spread of the virus. Experts say policies have broken down in ways that may put students and staff members at risk.

[Well b back 3,190]

4 hours ago, It's Character Forming said:

Thanks WBB

 

https://www.statnews.com/2020/09/09/astrazeneca-covid19-vaccine-trial-hold-patient-report/

 

this gives an update with the specific details (not that I’m really any the wiser about the condition).

 

this says it is different from the previous case which was unconnected to the vaccine. It’s not clear yet whether this case is linked to the vaccine.

 

the Economist has made the point with some medicines /vaccines, people with some conditions are ruled out from taking them.

 

As you say, this could and probably will make the “best case” timescale slip and that’s got to be a problem for Trump, silver linings etc 😉

Thanks

Now it seems we have the facts, this one has that disease I can’t spell and the other had MS. If being discharged today sounds promising it was a viral infection.

[Well b back 3,190]

Preparations being moved ahead interestingly by the people that tell us there will not be a vaccine until mid 2021

https://www.bbc.co.uk/news/business-54067499

 

[Well b back 3,190]

Interesting take on wether a vaccine will be ready by 1/11. Interestingly this doesn’t even include Oxford this is based around Pfizer and Moderna as it is about US vaccines.

https://medicalxpress.com/news/2020-09-coronavirus-vaccine-nov.html

[Well b back 3,190]

This is the absolute press release from Jenner themselves which mentions people already in the trial. Will just slow down extra bodies getting the vaccine.

Data under review for Phase II/III study

 

As part of the ongoing randomised controlled global trials of the coronavirus vaccine, our standard review process triggered a study pause to vaccination to allow review of safety data. This is a routine action which has to happen whenever there is a potentially unexplained illness in one of the studies, while it is investigated, ensuring we maintain the integrity of the trials. In large trials illnesses will happen by chance but must be independently reviewed to check this carefully. All routine follow-up appointments are continuing during this period. We are committed to the safety of our participants and the highest standards of conduct in our studies.

[Indy 3,283]

6 hours ago, Well b back said:

This is the absolute press release from Jenner themselves which mentions people already in the trial. Will just slow down extra bodies getting the vaccine.

Data under review for Phase II/III study

 

As part of the ongoing randomised controlled global trials of the coronavirus vaccine, our standard review process triggered a study pause to vaccination to allow review of safety data. This is a routine action which has to happen whenever there is a potentially unexplained illness in one of the studies, while it is investigated, ensuring we maintain the integrity of the trials. In large trials illnesses will happen by chance but must be independently reviewed to check this carefully. All routine follow-up appointments are continuing during this period. We are committed to the safety of our participants and the highest standards of conduct in our studies.

I’ve just had a chat with my mate, he’s said the unfortunate issue is that there are many causes of transverse myelitis, from infections to immune system disorders that attack the patient, which of course is one of the main problems with Covid. But could also be caused by other factors like  multiple sclerosis.

As soon as any major reaction come about the trial is immediately reviewed with a third party investigation into the exact cause to the patient. It’s very likely not directly connected but it might be a longer wait as above the way the vaccine works is in part to train the immune response thus certainly needs to be investigated.

Edited September 10, 2020 by Indy

[Van wink 2,994]

11 hours ago, Indy said:

I’ve just had a chat with my mate, he’s said the unfortunate issue is that there are many causes of transverse myelitis, from infections to immune system disorders that attack the patient, which of course is one of the main problems with Covid. But could also be caused by other factors like  multiple sclerosis.

As soon as any major reaction come about the trial is immediately reviewed with a third party investigation into the exact cause to the patient. It’s very likely not directly connected but it might be a longer wait as above the way the vaccine works is in part to train the immune response thus certainly needs to be investigated.

Thanks for that Indy, the fear is that it may be difficult to find a definitive cause for this persons illness?

At least he can be assured of the best attention and investigation.

[Well b back 3,190]

Our friends at The NY Times are not reporting much on the Vaccine today but this is regards their Universities. Let’s pray we have a better handle on it in the U.K. 

How U.S. universities botched quarantine

Our survey of 1,500 U.S. colleges has revealed at least 51,000 coronavirus cases and 60 deaths since the pandemic began. Natasha Singer, our reporter covering health and education technologies, wrote about a breakdown in college quarantines of students who have the coronavirus. She spoke to our On Tech newsletter about how students used social media to expose their universities’ poor handling of the crisis.

Tell me how students are using social media to shame their schools.

Natasha: Many people have seen the online videos of students stuck in quarantine or isolation documenting crummy or nonexistent university-provided meals. But what I found went deeper: Sick students are making videos about how they felt universities abandoned them once they tested positive and moved into special Covid dorms.

And there are a bunch of students who shared online their shock that virus-infected students or people who were waiting for tests were assigned to share a room, bathroom or dorm — conditions that they worried could foster infections. In some cases, their colleges then improved services for quarantined students.

[Well b back 3,190]

Are Oxford about to get overtaken ? In this report it says Pfizer are hoping for October ?

https://www.bbc.co.uk/news/health-54027269

[sonyc 5,492]

Have you read this article WBB? Interesting take on the global politics (Covax).

https://www.theguardian.com/world/2020/sep/11/the-covid-19-vaccine-gamble-where-bets-have-been-placed-and-why?

 

Edited September 11, 2020 by sonyc

[Well b back 3,190]

West Midlands news have just reported breaking news that the vaccine ( apparently there are 2 ) will commence in October in The West Midlands. More to follow, but apparently being distributed as we speak.

[sonyc 5,492]

2 minutes ago, Well b back said:

West Midlands news have just reported breaking news that the vaccine ( apparently there are 2 ) will commence in October in The West Midlands. More to follow, but apparently being distributed as we speak.

Crikey! 

Very encouraging. Well, more than that. Out of the blue or what!!!

[Pockthorpe 528]

Long while coming to this thread . You’ve done a great job WWB.

My eldest son has been working on the Oxford trial at NHS Southampton from the start . The first trial pause was not really communicated much in the press , this one for some reason has hit the headlines big time . Pausing is just standard procedure, in fact it’s the whole point of a trial. The really big worry they have is not about this incredibly unusual reaction to this participant ( maybe trial related maybe not ) but the fact that despite reassurances some of the other trial participants may be scared off and not be willing to continue. 

 

[Well b back 3,190]

4 minutes ago, Pockthorpe said:

Long while coming to this thread . You’ve done a great job WWB.

My eldest son has been working on the Oxford trial at NHS Southampton from the start . The first trial pause was not really communicated much in the press , this one for some reason has hit the headlines big time . Pausing is just standard procedure, in fact it’s the whole point of a trial. The really big worry they have is not about this incredibly unusual reaction to this participant ( maybe trial related maybe not ) but the fact that despite reassurances some of the other trial participants may be scared off and not be willing to continue. 

 

Welcome Pockthorpe

Yes we get most of our info from the foreign press ( we have come to accept lots of it as fact as so much has been proven correct ).

I am waiting to upload Midlands news as a link as they have just announced the vaccine will ( not could ) be started in the Midlands next month, but I fear from what they said Pfizer may have overtaken Oxford ( although I am sure they said there is approval for 2 to be used ). Apparently though they must get the flu jab administered first, so glad I am having mine 5/10.

[Well b back 3,190]

Well here it is. Go to 2 minutes 38 and prepare for this thread to begin to finish. For those in the know, which vaccine is being manufactured in Keele please ?. I have a feeling neither of these are Oxford.

https://www.bbc.co.uk/iplayer/episode/m000mh6d/midlands-today-late-news-11092020