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Well b back

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The announcement that the vaccine would be delayed from September to October I actually took to be good news.  I always thought the September date was a marketing thing but by delaying it I was more assured that it was genuine.    Am I odd in thinking this way?

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I’ve just had a chat with a contact from GSK, who is linked with a toxicologist in the vaccine team, it’s likely that vulnerable, will have vaccines first and the double dose is certainly the way forward. It’s this part of the trial which may delay the vaccine in September, but he thinks there might well be vaccines to those most at risk by end of September with mass immunisation by end of October. They are trying to ensure there’s no second winter spike leading to winter restrictions which as we can see during Christmas holidays would be mass family gatherings.

Just a snippet of info for you.

Edited by Indy
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So here’s a prediction reading between the lines of a few major speeches in the last couple of days.

I reckon the Oxford vaccine works, but only in part. I reckon as with the monkies you still can catch it, but it protects you from it moving onto your lungs. Even Fauci is suddenly now saying he thinks there will be a vaccine soon but it will only offer partial protection. Our scientists are saying the same.

Sounds good to me, happy to trading feeling tosh for a few days for being dead !!

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On 26/06/2020 at 20:53, Indy said:

I’ve just had a chat with a contact from GSK, who is linked with a toxicologist in the vaccine team, it’s likely that vulnerable, will have vaccines first and the double dose is certainly the way forward. It’s this part of the trial which may delay the vaccine in September, but he thinks there might well be vaccines to those most at risk by end of September with mass immunisation by end of October. They are trying to ensure there’s no second winter spike leading to winter restrictions which as we can see during Christmas holidays would be mass family gatherings.

Just a snippet of info for you.

Hi Indy

can you comment on my last post ? Do you reckon I have read between the lines correctly ?

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The news gets better. Thank you Brazil. This of course also means we are there ahead of China and USA.

Trial of Oxford COVID-19 vaccine starts in Brazil

Volunteers have begun taking part in Latin America’s first clinical trial for a vaccine against COVID-19.

Our vaccine work is progressing quickly. To ensure you have the latest information or to find out more about the trial, please check our latest COVID-19 research news or visit the COVID-19 trial website.

Volunteers in Brazil have begun receiving a trial vaccine against COVID-19, in Latin America’s first phase 3 COVID-19 clinical trial.

The trial officially began on Saturday 20th June and will enrol 5,000 volunteers across the country. Vaccinations will take place in Sao Paulo, Rio de Janeiro and a site in the Northeast of Brazil.

The Brazilian Health Regulatory Agency (ANVISA) approved the inclusion of Brazil in the clinical trials on 2nd June, which are being conducted in partnership with AstraZeneca. The trial is being sponsored entirely by Brazilian entrepreneurs.

Professor Sue Ann Costa Clemens, investigator and study coordinator from UNIFESP, said: 'It is an honour for me, as investigator and for my country to be selected to support the clinical development of this candidate vaccine and help the world to face a global challenge. This study has contributed to a major achievement in public health already, as the Brazilian Ministry of Health signed on June 27, an agreement for local production of ChAdOx1 nCoV-19 with AstraZeneca Brazil.'

Professor Andrew Pollard, Chief investigator of the Oxford Vaccine Trial at Oxford University said: 'It is a privilege to be working with the researchers at the Federal University of São Paulo – UNIFESP on the first COVID-19 vaccine trial in Latin America in the next stage of this important trial.

'The global coronavirus pandemic still presents an unprecedented threat to human health worldwide, but equally unprecedented is the impressive way researchers and scientists around the world have been able to collaborate on the clinical development work to combat this threat.'

The Federal University of São Paulo - UNIFESP is collaborating with the University of Oxford and the Oxford Vaccine Group on the Brazil trial. The Brazilian Ox1Cov-19 Vaccine Trial aims to find a vaccine that will prevent infection by SARS-CoV-2, the virus that causes COVID-19. The technical name of the vaccine is ChAdOx1 nCoV-19, as it is made from a virus called ChAdOx1, which is a weakened and non-replicating version of a common cold virus (adenovirus). The vaccine has been engineered to express the SARS-CoV-2 spike protein.

The vaccine was developed at the University of Oxford’s Oxford Jenner Institute and is currently on trial in the UK, where over 4,000 participants are already enrolled into the clinical trial and enrolment of an additional 10, 000 participants is planned.

About the Brazilian vaccine trial

The technical name of the vaccine is ChAdOx1 nCoV-19, as it is made from a virus called ChAdOx1, which is a weakened and non-replicating version of a common cold virus (adenovirus). The vaccine has been engineered to express the SARS-CoV-2 spike protein.

The vaccine was developed at the Oxford Jenner Institute and is currently on trial in the UK, where over 4,000 participants are already enrolled into the clinical trial and enrolment of an additional 10, 000 participants is planned.

The vaccine being used in the Brazilian trial is the same as that being used in the UK and South Africa.

The vaccine was made by adding genetic material – called spike glycoprotein – that is expressed on the surface of SARS-CoV-2 to the ChAdOx1 virus.
This spike glycoprotein is usually found on the surface of the novel coronavirus and is what gives the coronavirus its distinct spiky appearance.

These spikes play an essential role in laying a path for infection by the coronavirus. The virus that causes Covid-19 uses this spike protein to bind to ACE2 receptors on human cells.

ACE2 is a protein on the surface of many cell types. It is an enzyme that generates small proteins that then go on to regulate functions in the cell. In this way, the virus gains entry to the cells in the human body and causes Covid-19 infection.

Researchers have shown that antibodies produced against sections of the spike protein after natural infection are able to neutralize (kill) the virus when tested in the laboratory.

By vaccinating volunteers with ChAdOx1 nCoV-19, scientists hope to make the human body recognise and develop an immune response (i.e., develop antibodies) to the spike glycoprotein that will help stop the SARS-CoV-2 virus from entering human cells and causing Covid-19.

 
 

 

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1 hour ago, Well b back said:

Hi Indy

can you comment on my last post ? Do you reckon I have read between the lines correctly ?

WBB I can only say what I know, as said have a brother in law who’s an independent toxicologist who works with lots of companies, I’ve been told by a mutual friend who does the same line of work that the vaccine might need two shots of vaccine, then topped up each year. But they are working on dose size and frequency testing. That’s all I know, but sounds about in line with what you’ve posted.

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Good progress it seems, I fear the need to test these vaccines in Brazil might be overtaken by events here in the UK!

 

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22 minutes ago, Van wink said:

Good progress it seems, I fear the need to test these vaccines in Brazil might be overtaken by events here in the UK!

 

You mean a second wave is on its way ? 

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14 minutes ago, Well b back said:

You mean a second wave is on its way ? 

I fear that by September, maybe even before, we will be seeing seriously high numbers again.

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On 29/06/2020 at 22:08, Van wink said:

I fear that by September, maybe even before, we will be seeing seriously high numbers again.

Me to

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If all the pubs fill up this weekend then I am sure it will be much sooner. Be sensible fellow pink uners, please. 

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We need this development as the virus has never gone away. Without it I fear surges will be in the news again.

This article points out that it's been developed at such unprecedented speed. Extraordinary. 

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28 minutes ago, sonyc said:

We need this development as the virus has never gone away. Without it I fear surges will be in the news again.

This article points out that it's been developed at such unprecedented speed. Extraordinary. 

Without an effective vaccine, some of us may never be able to attend CR again.😰

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35 minutes ago, ricardo said:

Without an effective vaccine, some of us may never be able to attend CR again.😰

If this pandemic is as long lasting as Whitty has indicated, I imagine someone will work up a 50% capacity model just because it will create some kind of income for struggling clubs,  kind of socially distanced matches. Administratively a challenge, but I'm sure there would be a way. Our local paper today has McCall mentioning Wigan as a warning to clubs. They'll have to come up with some subsistence scheme  or clubs will fold like dominoes.

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1 hour ago, Herman said:

Is that a bad thing at the moment Ricky? 

Time is running out quicker for some of us.

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4 hours ago, ricardo said:

Time is running out quicker for some of us.

Me to Ricardo.

Several of us have followed this throughout and I will be shocked if at least one of the front runners doesn’t work. More so it’s a bit of a bad time for the world to fall out with China as one of my recent reports claims the medical authorities in China have now been approved and the Chinese military are indeed being vaccinated.

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4 minutes ago, Well b back said:

Me to Ricardo.

Several of us have followed this throughout and I will be shocked if at least one of the front runners doesn’t work. More so it’s a bit of a bad time for the world to fall out with China as one of my recent reports claims the medical authorities in China have now been approved and the Chinese military are indeed being vaccinated.

It's the best hope for the vulnerable if we are ever going to see a live match again.

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For anyone watching Andrew Marr, the CEO of NHS seemed very confident there will be a vaccine soon, the problems were the dosage and wether it can be taken with the flu jab.

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6 minutes ago, Well b back said:

Latest poll suggests the anti Vaxers are even putting a vaccine at risk in the U.K. 

https://www.telegraph.co.uk/global-health/science-and-disease/one-third-uk-may-not-get-coronavirus-vaccine-one-developed-new/

 

I guess if a vaccine can protect around 65% of the population from catching it or suffering from it - that is something. 

If the cases amongst those not vaccinated were to surge, I think the take-up would immediately become larger.

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3 minutes ago, Mark .Y. said:

I guess if a vaccine can protect around 65% of the population from catching it or suffering from it - that is something. 

If the cases amongst those not vaccinated were to surge, I think the take-up would immediately become larger.

I shall certainly be taking it. Getting to old to worry about long term side effects lol

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2 hours ago, Well b back said:

Latest poll suggests the anti Vaxers are even putting a vaccine at risk in the U.K. 

https://www.telegraph.co.uk/global-health/science-and-disease/one-third-uk-may-not-get-coronavirus-vaccine-one-developed-new/

 

Thanks, I can only hope that when a vaccine is available, people are persuaded by the fact that it will pretty much allow life to go back to normal.

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11 hours ago, Well b back said:

Latest poll suggests the anti Vaxers are even putting a vaccine at risk in the U.K. 

https://www.telegraph.co.uk/global-health/science-and-disease/one-third-uk-may-not-get-coronavirus-vaccine-one-developed-new/

 

The text doesn't quite support the headline.  It says that 1 in 5 probably or defiantly won't get a vaccine  which means that 80% probably or definitely will in my book.  

Even if it is 65% that is still a very good figure and will be enough to see this off in its current form.

This claim that 70-90% will be required to achieve herd immunity, where is that coming from?  No predictions of R0 even got close to requiring 90%. 70% sure, but not 90%. Perhaps that higher figure is to account or people that get the jab but on whom it has little or no effect but that analysis is contrary to the rest of the article.

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