Come on Sarah

[Well b back 3,190]

31 minutes ago, sonyc said:

Thanks as ever Wbb. 

I found this article (one of those suggested ones you get when you look to Google something) and felt it was educational about vaccines and the experience going through the testing phases you've mentioned earlier up this thread.

https://www.statnews.com/2020/05/26/moderna-vaccine-candidate-trial-participant-severe-reaction/

Nice one.

Thats really interesting because that explains the one I put on earlier about side effects. Shouldn’t put in opinion but maybe, just maybe that’s why Trump has forsaken his own countries vaccine for the Oxford vaccine. 

[Well b back 3,190]

23 minutes ago, Barbe bleu said:

Makes sense.   I posted elsewhere that I wondered if the italian peak being earlier than ours masked the true extent of the outbreak in italy if only excess deaths were considered.  Ie. that covid deaths were very high but flu deaths lower so lower overall excess deaths than if the covid had come along outside of the season where there is less saving to be had from infection control measures.

 

Then I got shouted down as people assumed i was making  a political point( which i wasn't)

Lol stick to this thread.

[It's Character Forming 1,160]

24 minutes ago, Well b back said:

Here is an excellent article about human challenge. It mentions how ‘ one day sooner ‘ the website to register your interest in human trials began, the fors and against, both ethically and scientifically and everything you can think of re the human challenge. In one of my earlier posts I mentioned how a few hundred had signed up, then updated that with a few thousand. The upto date figure is 26,000. Although there are a lot of reasons why this shouldn’t go ahead I wouldn’t bet against Mr Trump disregarding them all.

https://www.wired.co.uk/article/coronavirus-vaccine-challenge-trial

Really interesting. Given the reduced case numbers in the uk the case for challenge trials seems compelling to me. I mean, these are all volunteers. Back in 1982 we sent about 9,000 soldiers and marines to the South Atlantic, many died on both sides, if people are willing to volunteer now to help save lives, why shouldn’t they be allowed to?

[Well b back 3,190]

3 minutes ago, It's Character Forming said:

Really interesting. Given the reduced case numbers in the uk the case for challenge trials seems compelling to me. I mean, these are all volunteers. Back in 1982 we sent about 9,000 soldiers and marines to the South Atlantic, many died on both sides, if people are willing to volunteer now to help save lives, why shouldn’t they be allowed to?

It always has done to me as well, but that does throw up 1 thing I never thought of, that being if it works we will know it’s safe and works for this age group. What I hadn’t allowed for is there will be no evidence that it works on older age groups and consequently it may not get approved. However like I said earlier I reckon Trump would over ride everything to get his vaccine.

[Well b back 3,190]

Lots of news today, yet another vaccine goes into phase 1 human trials.

[Barbe bleu 815]

47 minutes ago, Well b back said:

It always has done to me as well, but that does throw up 1 thing I never thought of, that being if it works we will know it’s safe and works for this age group. What I hadn’t allowed for is there will be no evidence that it works on older age groups and consequently it may not get approved. However like I said earlier I reckon Trump would over ride everything to get his vaccine.

This is what we said earlier.  Phase 3 for less vulnerable groups but phase 2 for others.  If it passes both I cant see why it wouldn't be approved on a better than nothing basis? Not that I have any idea of the basis on which these decisions are made.

[Well b back 3,190]

Wow the Americans don’t like our vaccine. I will let you judge for yourselves if Adrian Hill etc are just mis representing or if the US are trying to just undermine the Oxford vaccine. What has made me think the US don’t like ours is the main US vaccine is reported to have serious side effects, but that is not mentioned. 
 

https://edition.cnn.com/2020/05/27/health/coronavirus-vaccine-oxford-eprise/index.html

[Well b back 3,190]

And then the other side of the US debate says the FDA may authorise, but not fully the use of the Oxford vaccine in October if it carries on with its good results. Again make your own mind up. If we had that choice here I am 59 and a type 2 diabetic, I would jump at it, my dad in his 80’s would jump at it, but I am sure my son at 16 would say no chance.

https://www.theverge.com/2020/5/26/21266591/covid-19-coronavirus-vaccine-fda-authorize-emergency-experimental

[sonyc 5,492]

French study here. Interesting  about mild infections but also the note about preventative treatment in the trachea to ward off a large viral load ....plus up to 2 years antibodies still present!

 

French team finds mild coronavirus infection does lead to antibodies

https://www.theguardian.com/world/2020/may/27/french-team-finds-mild-coronavirus-infection-does-lead-to-antibodies?

 

Edited May 27, 2020 by sonyc

[Well b back 3,190]

19 minutes ago, sonyc said:

French study here. Interesting  about mild infections but also the note about preventative treatment in the trachea to ward off a large viral load ....plus up to 2 years antibodies still present!

 

French team finds mild coronavirus infection does lead to antibodies

https://www.theguardian.com/world/2020/may/27/french-team-finds-mild-coronavirus-infection-does-lead-to-antibodies?

 

Some more good news.

Be careful doing all this research or if you have any teenagers they will be telling you, you are getting an unhealthy interest in the subject lol.

[sonyc 5,492]

25 minutes ago, Well b back said:

Some more good news.

Be careful doing all this research or if you have any teenagers they will be telling you, you are getting an unhealthy interest in the subject lol.

Haha, I don't go looking but read most of the online papers everyday and post stuff if I come across anything that stands out -on the CV thread (normally) or footballing ones. These are strange times with some of the biggest issues I've known in my life so I read even more trying to keep up!

Ps. I've already bored my family with what I've learned about agriculture today and fisheries last week. Actually it's all fairly shocking and deeply worrying. I thought I was well informed but I'm certainly not.

Edited May 27, 2020 by sonyc

[Well b back 3,190]

1 hour ago, sonyc said:

Haha, I don't go looking but read most of the online papers everyday and post stuff if I come across anything that stands out -on the CV thread (normally) or footballing ones. These are strange times with some of the biggest issues I've known in my life so I read even more trying to keep up!

Ps. I've already bored my family with what I've learned about agriculture today and fisheries last week. Actually it's all fairly shocking and deeply worrying. I thought I was well informed but I'm certainly not.

Know what you mean, but at least this thread people are only interested in the latest news on treatments and vaccines.

[It's Character Forming 1,160]

I see in SKorea they’ve had a spike of new cases with 79 reported, linked to a distribution warehouse. I hope they can quickly get it under control but I think until a vaccine is in place it’s going to be a bumpy road with restrictions reimposed from time to time.

[Van wink 2,994]

17 minutes ago, It's Character Forming said:

I see in SKorea they’ve had a spike of new cases with 79 reported, linked to a distribution warehouse. I hope they can quickly get it under control but I think until a vaccine is in place it’s going to be a bumpy road with restrictions reimposed from time to time.

Yes it certainly is going to be a bumpy road, community infection was very low in S Korea and their test and trace is now able to pick up new pockets of infection at speed.We desperately need a vaccine in the U.K.

[Well b back 3,190]

Maybe we can have their share.

A new poll found one in 5 Americans said they'd refuse a COVID-19 vaccine, which companies are racing to create

A new poll published Wednesday found that about one in five Americans said they'd refuse a COVID-19 vaccine should one become available.

Only about half of respondents to the poll, conducted by The Associated Press-NORC Center for Public Affairs Research, said they would get such a vaccine, while 31% said they were not yet sure whether they would get one.

The poll surveyed 1,056 adults and was conducted May 14-18. The results were released on the same day when the US reached a grim milestone of 100,000 deaths from the novel coronavirus, which causes the illness known as COVID-19.

"There's still a large amount of uncertainty around taking the vaccine," Caitlin Oppenheimer, the senior vice president of Public Health at NORC, told the AP. "There is a lot of opportunity to communicate with Americans about the value and the safety of a vaccine."

ADVERTISING

Experts have touted a COVID-19 vaccine as the solution to allowing the world to return to something resembling normality. The Centers for Disease Control and Prevention describes vaccinations as "one of the best ways to put an end to the serious effects of certain diseases."

Respondents' uncertainty in this case, however, could have to do with the unprecedented circumstances surrounding COVID-19, which has prompted a worldwide race to condense a development process that normally takes several years into what scientists hope could be 12 to 18 months.

Melanie Dries, 56, from Colorado, told the AP she was not an anti-vaxxer but was concerned about getting a COVID-19 vaccine in the near feature, saying it "causes me to fear that it won't be widely tested as to side effects."

Dr. Francis Collins, the director of the National Institutes of Health, told the AP in a previous interview that he "would not want people to think that we're cutting corners because that would be a big mistake."

"I think this is an effort to try to achieve efficiencies, but not to sacrifice rigor," he said, adding that "definitely the worst thing that could happen is if we rush through a vaccine that turns out to have significant side effects."

The Trump administration announced a vaccine-distribution program, dubbed Operation Warp Speed, meant to have 300 million doses in stock by January. The Department of Health and Human Services also promised earlier this week to provide "up to $1.2 billion" in funds to a laboratory at Oxford University working to develop a vaccine, The New York Times reported.

"It's always better to underpromise and overdeliver," Dr. William Schaffner, an infectious-disease expert at Vanderbilt University Medical Center, told the AP. "The unexpected looms large, and that's why I think for any of these vaccines, we're going to need a large safety database to provide the reassurance."

The AP-NORC poll found that 20% of Americans believed a coronavirus vaccine would be available to the public this year, with a majority saying it was more likely that a vaccine would be available next year.

About seven in 10 of those who said they would get the coronavirus vaccine said they believed life would not return to normal without one, with other top reasons for getting vaccinated including protecting themselves, their families, and the community.

"I'm definitely going to get it," Brandon Grimes, 35, from Austin, Texas, told the AP. "As a father who takes care of his family, I think ... it's important for me to get vaccinated as soon as it's available to better protect my family."

[Well b back 3,190]

One day sooner’s reasons why human challenge trials should start now.

https://www.statnews.com/2020/05/28/challenge-trials-speed-development-covid-19-vaccine-start-planning-now/

[Well b back 3,190]

So here is just about where we are, a summing up of promising vaccines and drugs

https://www.medicalnewstoday.com/articles/science-vs-covid-19-vaccine-trial-wins-and-other-hopeful-findings

[Barbe bleu 815]

13 hours ago, Well b back said:

So here is just about where we are, a summing up of promising vaccines and drugs

https://www.medicalnewstoday.com/articles/science-vs-covid-19-vaccine-trial-wins-and-other-hopeful-findings

Thanks,

Good news on three fronts in there. What caught my eye is the cross reactivity  of (old) SARS antibodies. Possibly  evidence/hint that pre exposure to another coronavirus might give protection to this one?  Obviously very limited study. I am not sure what to make of the implications for UK epidemiology but surely if antibodies for a different (and ten year old) coronavirus are still effective it does hint that mutation rate is  not a huge issue.

 

[Mark .Y. 351]

44 minutes ago, Barbe bleu said:

Thanks,

Good news on three fronts in there. What caught my eye is the cross reactivity  of (old) SARS antibodies. Possibly  evidence/hint that pre exposure to another coronavirus might give protection to this one?  Obviously very limited study. I am not sure what to make of the implications for UK epidemiology but surely if antibodies for a different (and ten year old) coronavirus are still effective it does hint that mutation rate is  not a huge issue.

 

Yes Bb, I think that I or somebody else has previously referenced a report that suggested if the virus does mutate, it often becomes weaker. Bizarre as it sounds, almost seems to learn that it's need to reproduce is best served by not killing it's host

[Barbe bleu 815]

2 hours ago, Mark .Y. said:

Yes Bb, I think that I or somebody else has previously referenced a report that suggested if the virus does mutate, it often becomes weaker. Bizarre as it sounds, almost seems to learn that it's need to reproduce is best served by not killing it's host

I get that.  I think  old SARS was a victim of this, too virulent for it's own good and incapacitating your carrier isnt good for any virus. Mutation anybfeom this trend can only be helpful to its 'survival'

But its not clear that would apply here.  Yes it does kill a lot but it is also asymptomatic/sub clinical in much more. It also seems that the virus does linger. Asymptomatic and lingering seem the ideal combination so not a bad evolutionary fit.

I'm not sure the dynamics that would force a down regulation are really at play here. 

I'm happy it is relatively stable

Edited May 29, 2020 by Barbe bleu

[Well b back 3,190]

Here’s the latest on anti body therapies

https://www.scientificamerican.com/article/coronavirus-antibody-therapies-raise-hopes-and-skepticism/

 

[Well b back 3,190]

Today Jenner and AstraZeneca have signed a new agreement with Oxford Biomedical which winds up manufacture to even bigger levels. Not bad for something that as yet is not proven, or is it ? Who knows.

Released : 28.05.2020 12:16

RNS Number : 2451O

Oxford Biomedica PLC

28 May 2020

 

 

The information contained within this announcement is deemed by the Company to constitute inside information as stipulated under the Market Abuse Regulation (EU) No. 596/2014. Upon the publication of this announcement via the Regulatory Information Service, this inside information is now considered to be in the public domain.

 

 

Oxford Biomedica Signs Clinical & Commercial Supply Agreement with AstraZeneca, for manufacture of COVID-19 vaccine candidate 

 

          

Oxford, UK - 28 May, 2020: Oxford Biomedica plc (LSE:OXB) ("Oxford Biomedica" or "the Group"), a leading gene and cell therapy group, announced today that it has signed a one year Clinical & Commercial Supply Agreement with AstraZeneca UK Ltd ("AstraZeneca"). The Agreement relates to the GMP manufacture of the adenovirus vector based COVID-19 vaccine candidate, AZD1222, which recently entered clinical trials at multiple sites in the UK. Oxford Biomedica is working alongside AstraZeneca and other manufacturing organisations to provide large scale manufacturing capacity for this vaccine candidate.

 

As part of the Clinical & Commercial Supply Agreement, AstraZeneca will have access to Oxford Biomedica's new 7,800 m² commercial manufacturing centre Oxbox, located in Oxford, UK. In April 2020 Oxford Biomedica announced that it had joined a consortium including the Jenner Institute in relation to the potential for large scale manufacture of AZD1222. On 30 April 2020 AstraZeneca and Oxford University subsequently announced an agreement to enable global development, manufacturing and distribution of the vaccine.

 

The initial agreement requires Oxford Biomedica to provide AstraZeneca with multiple batches of vaccine, the majority of which are expected to be produced throughout 2020. The production will be from one of the Group's recently approved GMP suites in Oxbox. The Commercial Supply agreement may be extended further depending on the progression of the programme.

 

 

John Dawson, Chief Executive Officer of Oxford Biomedica, said: "We are proud to be a part of the manufacturing consortium working with the Jenner Institute at University of Oxford, for the early manufacturing and scale up of this viral vector based candidate for COVID-19. Following the recent announcement of an agreement between the University of Oxford and AstraZeneca, we are very pleased to be one of AstraZeneca's global network of manufacturing partners, and look forward to them being the third company to have rapid access to our specialised manufacturing capacity for this vaccine candidate at Oxbox".

 

 

 

 

-Ends-

Enquiries:
Oxford Biomedica plc   John Dawson, Chief Executive Officer Stuart Paynter, Chief Financial Officer Catherine Isted, Head of Corporate Development & IR	T: +44 (0)1865 783 000 T: +44 (0)1865 783 000 T: +44 (0)1865 954 161 / E: ir@oxb.com
Consilium Strategic Communications   Mary-Jane Elliott/Matthew Neal	T: +44 (0)20 3709 5700

 

 

 

 

About Oxford Biomedica

Oxford Biomedica (LSE:OXB) is a leading, fully integrated, gene and cell therapy group focused on developing life changing treatments for serious diseases. Oxford Biomedica and its subsidiaries (the "Group") have built a sector leading lentiviral vector delivery platform (LentiVector®), which the Group leverages to develop in vivo and ex vivo products both in-house and with partners. The Group has created a valuable proprietary portfolio of gene and cell therapy product candidates in the areas of oncology, ophthalmology, CNS disorders, liver diseases and respiratory disease. The Group has also entered into a number of partnerships, including with Novartis, Bristol Myers Squibb, Sanofi, Axovant Gene Therapies, Orchard Therapeutics, Santen, Boehringer Ingelheim, the UK Cystic Fibrosis Gene Therapy Consortium and Imperial Innovations, through which it has long-term economic interests in other potential gene and cell therapy products. Oxford Biomedica is based across several locations in Oxfordshire, UK and employs more than 550 people. Further information is available at www.oxb.com

 

About Oxbox

Oxbox is Oxford Biomedica's new 7,800 m² commercial manufacturing centre, located in Oxford, UK. Phase I, which will be operational in 2020, is 4,200 m² of developed area consisting of six Good Manufacturing Practices ("GMP") clean room suites - four for vector production and two for fill-finish, warehousing and cold chain facilities and support laboratories. The Company received MHRA approval for the first two suites in Oxbox earlier this month. Phase II will provide for flexible expansion for a further six GMP clean room suites. This world class facility is expected to more than double Oxford Biomedica's manufacturing capacity, supporting further growth in revenues.

 

 

The person who arranged for the release of this announcement on behalf of Oxford Biomedica plc was John Dawson, Chief Executive Officer.

 

This information is provided by RNS, the news service of the London Stock Exchange. RNS is approved by the Financial Conduct Authority to act as a Primary Information Provider in the United Kingdom. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact rns@lseg.comor visit www.rns.com.

 

END

 

 

[Well b back 3,190]

Wow 99 % sure it works, that’s a big statement. In negotiations for stage 3 to be in U.K.

Wonder if Mr Trump wishes he hadn’t fell out with the Chinese and WHO

 

Coronavirus: 99% confident that COVID-19 vaccine will work, says Chinese firm

The Beijing-based biotech company is currently building a commercial plant with the objective of delivering 100 million doses.

Tom Cheshire

Asia correspondent @chesh

Saturday 30 May 2020 02:29, UK

• COVID-19
• CHINA
• CORONAVIRUS

Image:Inside biotech company Sinovac, where work is taking place to create a coronavirus vaccine

•  
   
•  
   
•  
   
•  

Why you can trust Sky News 

Chinese scientists working on a COVID-19 vaccine have told Sky News they are "99%" sure it will be effective.

Sinovac, a Beijing-based biotech company, currently has its coronavirus vaccine in stage 2 trials, with more than 1,000 volunteers participating. Sky News is the first British broadcaster to visit its labs.

 

The company also said it is in preliminary talks to hold stage 3 trials - the final part of the trials process - in the UK.

Image:Samples of the vaccine are being worked on

Sky News asked Luo Baishan, a researcher at Sinovac, whether he thought the vaccine would be successful.

"Yes, yes. It must be successful… 99% [sure]," he replied.

Advertisement

Last month Sinovac published results in the academic journal Science which showed the vaccine, called CoronaVac, protects monkeys from infection by the coronavirus.

[Mark .Y. 351]

9 hours ago, Well b back said:

Wow 99 % sure it works, that’s a big statement. In negotiations for stage 3 to be in U.K.

Wonder if Mr Trump wishes he hadn’t fell out with the Chinese and WHO

 

 

Yes, a very bold statement indeed - hope they are correct.

I wonder why they would want to do stage 3 in the UK when the Oxford people are already saying there might not be enough cases around to test it properly. You would have thought somewhere like Brazil would have been the ideal place to test it ??  

[Van wink 2,994]

2 hours ago, Mark .Y. said:

Yes, a very bold statement indeed - hope they are correct.

I wonder why they would want to do stage 3 in the UK when the Oxford people are already saying there might not be enough cases around to test it properly. You would have thought somewhere like Brazil would have been the ideal place to test it ??  

 We hear there are 8000 new infections a day In England and suggestions that R is over one in some regions, that doesn’t really seem to tie up with statements for Oxford that infection rate in U.K. is so low it makes trialling vaccine difficult. 

[Well b back 3,190]

Be nice if they both work. Hopefully at least part of the deal is if it does work we get some of their first doses.

One other thing I do find amiss is that if anyone was going to do human challenge trials it would be the Chinese as their people I assume would be more willing. Maybe they are so certain as this has already been done, although I very much doubt it.

[Mark .Y. 351]

1 hour ago, Van wink said:

 We hear there are 8000 new infections a day In England and suggestions that R is over one in some regions, that doesn’t really seem to tie up with statements for Oxford that infection rate in U.K. is so low it makes trialling vaccine difficult. 

Yes VW, I kind of agree. It does seem strange doesn't it. But I am as sure as I can be that I read that they are considering having to take trials out of the UK. Hopefully, somebody could explain it...........

[......and Smith must score. 1,336]

13 hours ago, Well b back said:

Wow 99 % sure it works, that’s a big statement. In negotiations for stage 3 to be in U.K.

Wonder if Mr Trump wishes he hadn’t fell out with the Chinese and WHO

Probably best to take anything the Chinese say with a very large pinch of salt.

Only 1% less than they would say in North Korea 😀

 

[Van wink 2,994]

10 minutes ago, Mark .Y. said:

Yes VW, I kind of agree. It does seem strange doesn't it. But I am as sure as I can be that I read that they are considering having to take trials out of the UK. Hopefully, somebody could explain it...........

I've read that too as has Well B Back, I'm not questioning that thats what they've said, I'm just having trouble understanding how the two relate to each other in these circumstances. Im sure somebody can explain.

Edited May 31, 2020 by Van wink

[Well b back 3,190]

53 minutes ago, Van wink said:

I've read that too as has Well B Back, I'm not questioning that thats what they've said, I'm just having trouble understanding how the two relate to each other in these circumstances. Im sure somebody can explain.

I will watch the press releases over the next couple of days with interest.

Dont forget though some of the reports will be fictional, but as we have seen a lot of the initial stories seem to turn out as fact.